PI Name: Tony Simon
Institution: Stanford


The central aim of the proposed research program is to evaluate a set of novel hypotheses about the basis of nonverbal cognitive impairments in children with chromosome 22q11.2 deletion syndrome (22q). The proposed series of studies transforms the exploratory analyses into a direct test of a new neurocognitive explanation. Specifically, we now propose that early developmental changes occur in the structure and function of well-established, largely subcortical, neural circuits for basic spatiotemporal information processing.