PI Name: Lori Altshuler
Institution: UCLA


This Collaboration and Service project will explore whether abnormal white matter anatomical connections may underlie the gray matter (functional) abnormalities previously seen in fMRI data from subjects with bipolar disorder. We are collecting, in the same subjects, both diffusion tensor imaging (DTI)-tractography data and fMRI data. A combined analysis of both datasets will enable us to assess the integrity of white matter tracts and the extent to which the degree of white matter integrity correlates with degree of neuronal circuit function. Specifically, we will explore whether the integrity of white matter tracts that connect the amygdala to orbitofrontal cortex predicts the functional connectivity in those brain regions.