Connectomics, TR&D 2, became an area of interest as a result of ongoing work to transition from computational anatomy, assessed with structural MRI, to DTI and HARDI as a means of mapping brain connectivity and identifying the factors that affect it. Before researchers began focusing on connectomics, developing methods for Tensor-Based Morphometry (TBM) and tools for deformable registration and population analysis of brain MRI scans were primary focuses.

The success of these projects exposed a community of researchers and collaborators who are collecting DTI data. New collaborators were carefully sought out to offer datasets and mathematical/analytical challenges of unusual kinds (HARDI, genomics). This steady infusion of new ideas ensures that our P41 Resource remains innovative, and responds to the changing needs of the field and our collaborators. This project is greatly helped by the tools and expertise being developed in the other TR&D projects.