NEWS AND
PUBLICATIONS

FEATURED

Twenty years ago, a seminal research study suggested that genetically vulnerable women–those with one copy of the ApoE4 gene variant–were 50% more likely to develop Alzheimer’s disease than men with the same genetic profile.

In August, LONI researchers published a study in JAMA Neurology that used increased statistical power to reexamine the finding, and discovered something new and surprising about the link between age, gender, and Alzheimer’s risk.

Data from more than 57,000 people were used for the study, thanks to the Global Alzheimer’s Association Interactive Network (GAAIN), a worldwide big data dementia science initiative.

Click here to view the article in JAMA Neurology.

PUBLICATIONS

Below is a summary of all publications organized by type and year in reverse chronological order since the inception of the LONIR in 1998.

 

Publications since May 2017:

  1. Shi Y & Toga AW 2017 Connectome imaging for mapping human brain pathways, Molecular Psychiatry, in press. NIHMS#: NIHMS855615.
  2. Gahm JK & Shi Y 2017 Holistic mapping of striatum surfaces in the Laplace-Beltrami embedding space, Proc. MICCAI, in press. NIHMS#:NIHMS879181.
  3. Sun W, Amezcua L & Shi Y 2017 FOD restoration for enhanced mapping of white matter lesion connectivity, Proc.MICCAI, in press.NIHMS#: NIHMS879175.
  4. Wang J & Shi Y 2017 Kernel-regularized ICA for computing functional topography from resting-state fMRI, Proc.MICCAI, in press.NIHMS#: NIHMS879178.
  5. Wang J, Aydogan D, Varma R, Toga AW & Shi Y 2017 Topographic regularity for tract filtering in brain connectivity, Proc. IPMI, 263-274.NIHMS#: NIHMS870081.
  6. Neu S, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang L-S, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang J-J, HsuW-C, Chen Y-L & Toga AW Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer’s Disease, JAMA Neurology, 28 August.
  7. Moyer D, Gutman BA, Faskowitz J, Jahanshad N, Thompson PM. Continuous representations of brain connectivity using spatial point processes. Med Image Anal. 2017 Oct;41:32-39. doi: 10.1016/j.media.2017.04.013. Epub 2017 Apr 28.
  8. Vikash Gupta, Sophia Thomopoulos, Faisal Rashid, Paul Thompson (2017). FiberNet: An ensemble deep learning framework for clustering white matter fibers in the brain, Proc. MICCAI, in press. http://www.biorxiv.org/content/early/2017/05/22/141036
  9. Dennis EL, Rashid F, Ellis MU, Babikian T, Vlasova RM, Villalon-Reina JE, Jin Y, Olsen A, Mink R, Babbitt C, Johnson J, Giza CC, Thompson PM, Asarnow RF. Diverging white matter trajectories in children after traumatic brain injury: The RAPBI study. Neurology. 2017 Apr 11;88(15):1392-1399. **let’s print this with the cover on as it got the cover of NEUROLOGY
  10. Nir TM, Jahanshad N, Villalon-Reina JE, Isaev D, Zavaliangos-Petropulu A, Zhan L, Leow AD, Jack CR Jr, Weiner MW, Thompson PM; Alzheimer’s Diseaase Neuroimaginng Initiative (ADNI). Fractional anisotropy derived from the diffusion tensor distribution function boosts power to detect Alzheimer’s disease deficits. Magn Reson Med. 2017 Mar 7. doi: 10.1002/mrm.26623.
  11. Petrov DM, Ivanov A, Faskowitz J, Gutman B, Moyer D, Villalon J, Jahanshad N & Thompson P 2017 Evaluating 35 Methods to Generate Structural Connectomes Using Pairwise Classification, Proc. MICCAI, in press. http://www.biorxiv.org/content/early/2017/06/19/151993
  12. Kurmukov A, Ananyeva M, Dodonova Y, Gutman B, Faskowitz J, Jahanshad N, Thompson P & Zhukov L 2017 Classifying phenotypes based on the community structure of human brain networks, MICCAI GRAIL Workshop, in press.
  13. Ding Z, Fleishman G, Yang X, Thompson P, Kwitt R, Niethammer M & The Alzheimer’s Disease Neuroimaging Initiative 2017 Fast Predictive Simple Geodesic Regression, MICCAI DLMIA (Deep Learning in Medical ImageAnalysis) workshop, accepted.
  14. Petrov DM, Gutman BA, Yu SH, van Erp TGM, Turner JA, Schmaal L, Veltman D, Wang L, Alpert K, Isaev D, Zavaliangos-Petropulu A, Ching CRK, Calhoun V, Glahn D, Sattertwaite T, Andreasen OA, Borgwardt S, Howells F, Groenewold N, Voineskos A, Radua J, Potkin SG, Crespo-Facorro B, Tordesillas-Gutierrez D, Shen L, Lebedeva I, Spalletta G, Donohoe G, Kochunov P, Rosa PGP, James A, Dannlowski U, Baune BT, Aleman A, Gotlib IH, Walter H, Walter M, Soares JC, Gur RC, Doan NT, Agartz I, Lars T. Westlye, Harrisberger F, Riecher-Rössler A, Uhlmann A, Stein DJ, Dickie EW, Pomarol-Clotet E, Fuentes-Claramonte P, Canales-Rodriguez EJ, Salvador R, Huang AJ, Roiz-Santianez R, Cong S, Tomyshev A, Piras F, Vecchio D, Banaj N, Ciullo V, Hong E, Busatto G, Zanetti MV, Serpa MH, Cervenka S, Kelly S, Grotegerd D, Sacchet MD, Veer IM, Li M, Wu MJ, Irungu B & Thompson PM 2017 Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging, MICCAI Machine Learning in Medical Imaging Workshop, also posted on biorXiv, July 2017 http://www.biorxiv.org/content/early/2017/07/21/166496
  15. Zhu D , Riedel BC, Jahanshad N, Groenewold N, Stein D, Gotlib IH, Dima D, Cole J, Fu CHY, Walter H, Veer IM, Frodl T, Schmaal L, Veltman DJ & Thompson PM 2017 Classification of Major Depressive Disorder via Multi-Site Weighted LASSO Model, Proc. MICCAI, in press. https://arxiv.org/abs/1705.10312
  16. Moyer DC, Gutman BA, Jahanshad N & Thompson PM 2017 Product Space Decompositions for Continuous Representations of Brain Connectivity, MICCAI Machine Learning in Medical Imaging Workshop, Sept. 10.
  17. Wang Q, Sun M, Zhan L, Thompson P, Ji S & Zhou J 2017 Multi-Modality Disease Modeling via Collective Deep Matrix Factorization, In Proceedings of KDD, Halifax, Canada. Available at: http://www.kdd.org/kdd2017/papers/view/multi-modality-disease-modeling-viacollective-deep-matrix. factorization
  18. Zhan L, Jenkins LM, Wolfson OE, GadElkarim JJ, Thompson PM, Ajilore OA, Chung MK & Leow AD 2017 The Significance of Negative Correlations in Brain Connectivity, J Comp Neurol., Jul 4. doi: 10.1002/cne.24274. [Epub ahead of print].
  19. Huang C, Thompson PM, Wang Y, Yu Y, Zhang J, Kong D, Knickmeyer RC, Colen RR, Zhu H & the Alzheimer’s Disease Neuroimaging Initiative 2017 FGWAS: Functional Genome-Wide Association Analysis, Neuroimage, Jul 20; 159:107-121. doi: 10.1016/j. neuroimage.2017.07.030. [Epub ahead of print]
  20. Kochunov P, Coyle TR, Rowland LM, Jahanshad N, Thompson PM, Kelly S, Du X, Sampath H, Bruce H, Chiappelli J, Ryan M, Fisseha F, Savransky A, Adhikari B, Chen S, Paciga SA, Whelan CD, Xie Z, Hyde CL, Chen X, Schubert CR, O’Donnell P & Hong LE 2017 Association of White Matter With Core Cognitive Deficits in Patients WithSchizophrenia, JAMA Psychiatry, Aug 2. doi: 10.1001/ jamapsychiatry.2017.2228. [Epub ahead of print] PMID: 28768312
  21. Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway S, Correia S, Sperling RA, Chhatwal JP, Mayeux R, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC & Dominantly Inherited Alzheimer Network (DIAN), Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial MRI study, Alzheimers Dement, Jul 21. pii: S1552-5260(17)32521-9. doi: 10.1016/j.jalz.2017.06.2268. [Epub ahead of print] PMID: 28738187.
  22. Chiesa PA, Cavedo E, Lista S, Thompson PM, Hampel H & Alzheimer Precision Medicine Initiative (APMI) 2017 Revolution of Resting-State Functional Neuroimaging Genetics in Alzheimer’s Disease, Trends in Neuroscience, Aug. 40(8):469-480. doi: 10.1016/j. tins.2017.06.002. Epub 2017 Jul 3. Review.
  23. Brouwer RM, Panizzon MS, Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI, Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM & Hulshoff Pol HE 2017 Genetic influences on individual differences in longitudinal changes in global andsubcortical brain volumes: Results of the ENIGMA plasticity working group, Hum Brain Mapp, Sep.
    38(9):4444-4458. doi: 10.1002/hbm.23672. Epub 2017 Jun 5.
  24. Walton E, Hibar DP, van Erp TGM, Potkin SG, Roiz-Santiañez R, Crespo-Facorro B, Suarez-Pinilla P, van Haren NEM, de Zwarte SMC, Kahn RS, Cahn W, Doan NT, Jørgensen KN, Gurholt TP, Agartz I, Andreassen OA, Westlye LT, Melle I, Berg AO, Morch-Johnsen L, Færden A, Flyckt L, Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP), Jönsson EG, Hashimoto R, Yamamori H, Fukunaga M, Jahanshad N, De Rossi P, Piras F, Banaj N, Spalletta G, Gur RE, Gur RC, Wolf DH, Satterthwaite TD, Beard LM, Sommer IE, Koops S, Gruber O, Richter A, Krämer B, Kelly S, Donohoe G, McDonald C, Cannon DM, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley HC, Neilson E, Calhoun VD, Thompson PM, Turner JA, Ehrlich S & Karolinska Schizophrenia Project consortium (KaSP) 2017 Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium, Psychol Med., May. 26:1-13. doi: 10.1017/S0033291717001283.
  25. Lin A, Ching CRK, Vajdi A, Sun D, Jonas RK, Jalbrzikowski M, Kushan-Wells L, Pacheco Hansen L, Krikorian E, Gutman B, Dokoru D, Helleman G, Thompson PM & Bearden CE 2017 Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry, Journal of Neuroscience, Jun 28; 37(26):6183-6199. doi: 10.1523/JNEUROSCI.3759-16.2017. Epub 2017 May 23.
  26. Rentería ME, Schmaal L, Hibar DP, Couvy-Duchesne B, Strike LT, Mills NT, de Zubicaray GI, McMahon KL, Medland SE, Gillespie NA, Hatton SN, Lagopoulos J, Veltman DJ, van der Wee N, van Erp TGM, Wittfeld K, Grabe HJ, Block A, Hegenscheid K, Völzke H, Veer IM, Walter H, Schnell K, Schramm E, Normann C, Schoepf D, Konrad C, Zurowski B, Godlewska BR, Cowen PJ, Penninx BWJH, Jahanshad N, Thompson PM, Wright MJ, Martin NG, Christensen H & Hickie IB 2017 Subcortical brain structure and suicidal behaviour in major depressive
    disorder: a meta-analysis from the ENIGMA-MDD working group, Transl Psychiatry, May; 7(5):e1116.
  27. Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, Versace A, Bilderbeck AC, Uhlmann A, Mwangi B, Krämer B, Overs B, Hartberg CB, Abé C, Dima D, Grotegerd D, Sprooten E, Bøen E, Jimenez E, Howells FM, Delvecchio G, Temmingh H, Starke J, Almeida JRC, Goikolea JM, Houenou J, Beard LM, Rauer L, Abramovic L, Bonnin M, Ponteduro MF, Keil M, Rive MM, Yao N, Yalin N, Najt P, Rosa PG, Redlich R, Trost S, Hagenaars S, Fears SC, Alonso-Lana S, van Erp TGM, Nickson T, Chaim-Avancini TM, Meier TB, Elvsåshagen T, Haukvik UK, Lee WH, Schene AH, Lloyd AJ, Young AH, Nugent A, Dale AM, Pfennig A, McIntosh AM, Lafer B, Baune BT, Ekman CJ, Zarate CA, Bearden CE, Henry C, Simhandl C, McDonald C, Bourne C, Stein DJ, Wolf DH, Cannon DM, Glahn DC, Veltman DJ, Pomarol-Clotet E, Vieta E, Canales-Rodriguez EJ, Nery FG, Duran FLS, Busatto GF, Roberts G, Pearlson GD, Goodwin GM, Kugel H, Whalley HC, Ruhe HG, Soares JC, Fullerton JM, Rybakowski JK, Savitz J, Chaim KT, Fatjó-Vilas M, Soeiro-de-Souza MG, Boks MP, Zanetti MV, Otaduy MCG, Schaufelberger MS, Alda M, Ingvar M, Phillips ML, Kempton MJ, Bauer M, Landén M, Lawrence NS, van Haren NEM, Horn NR, Freimer NB, Gruber O, Schofield PR, Mitchell PB, Kahn RS, Lenroot R, Machado-Vieira R, Ophoff RA, Sarró S, Frangou S, Satterthwaite TD, Hajek T, Dannlowski U, Malt UF, Arolt V, Gattaz WF, Drevets WC, Caseras X, Agartz I, Thompson PM & Andreassen OA 2017 Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group, Mol Psychiatry, May. doi: 10.1038/mp.2017.73.
    [Epub ahead of print].
  28. Fong SS, Paholpak P, Daianu M, Deutsch MB, Riedel BC, Carr AR, Jimenez EE, Mather MM, Thompson PM & Mendez MF 2017 The attribution of animacy and agency in frontotemporal dementia versus Alzheimer’s disease, Cortex, Jul. 92:81-94. doi: 10.1016/j. cortex.2017.03.019.
  29. Walton E, Hibar DP, van Erp TG, Potkin SG, Roiz-Santiañez R, Crespo-Facorro B, Suarez-Pinilla P, Van Haren NE, de Zwarte SM, Kahn RS, Cahn W, Doan NT, Jørgensen KN, Gurholt TP, Agartz I, Andreassen OA, Westlye LT, Melle I, Berg AO, Mørch-Johnsen L, Faerden A, Flyckt L, Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP), Jönsson EG, Hashimoto R, Yamamori H, Fukunaga M, Preda A, De Rossi P, Piras F, Banaj N, Ciullo V, Spalletta G, Gur RE, Gur RC, Wolf DH, Satterthwaite TD, Beard LM, Sommer IE, Koops S, Gruber O, Richter A, Krämer B, Kelly S, Donohoe G, McDonald C, Cannon DM, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley HC, Neilson E, Calhoun VD, Thompson PM, Turner JA & Ehrlich S 2017 Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium, Acta Psychiatr Scand, May. 135(5):439-447. doi: 10.1111/acps.12718.
  30. BRAINS (Brain Imaging in Normal Subjects) Expert Working Group, Shenkin SD, Pernet C, Nichols TE, Poline JB, Matthews PM, van der Lugt A, Mackay C, Lanyon L, Mazoyer B, Boardman JP, Thompson PM, Fox N, Marcus DS, Sheikh A, Cox SR, Anblagan D, Job DE, Dickie DA, Rodriguez D & Wardlaw JM 2017 Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group, Neuroimage, Jun. 153:399-409. doi: 10.1016/j.neuroimage.2017.02.030.
    31. Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung JY, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin NH, Wright MJ, Öngür D, Buckner R, Roffman J, Thompson PM & Smoller JW 2017 Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia, Mol Psychiatry, Aug. 22(8):1224.
  31. Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung JY, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin NH, Wright MJ, Öngür D, Buckner R, Roffman J, Thompson PM & Smoller JW 2017 Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia, Mol Psychiatry, Aug. 22(8):1224.
  32. Watson C, Busovaca E, Foley JM, Allen IE, Schwarz CG, Jahanshad N, Nir TM, Esmaeili-Firidouni P, Milanini B, Rosen H, Carmichael OT, Thompson PM & Valcour VG 2017 White matter hyperintensities correlate to cognition and fiber tract integrity in older adults with HIV, J Neurovirol, Jun. 23(3):422-429. doi: 10.1007/s13365-016-0509-5.
  33. Van Rooij D, Anagnostou E, Arango C, Auzias G, Behrmann M, Calderoni S, Daly E, Deruelle C, Dimartino A, Dinstein I, Durston S, Ecker C, Fair D, Fedor J, Fitzgerald J, Freitag C, Gallagher L, Gori I, Haar S, Hoekstra L, Jahanshad N, Jalbrzikowski M, Janssen J, Lerch J, Luna B, McGrath J, Muratori F, Murphy C, Murphy DGM, O’Hearn K, Oranje B, Parellada M, Retico A, Rubia K, Shook D, Taylor M, Thompson PM, Tosetti M, Wallace G, Zhou F & Buitelaar JK 2017 Subcortical brain volume differences between patients with autism spectrum disorders (ASD) and healthy individuals across the lifespan: an ENIGMA collaboration, American Journal of Psychiatry, in press, Aug.

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