Alzheimer’s Disease

PI Name: Liana Apostolova
Institution: UCLA

Abstract:

Mild cognitive impairment (MCI) is a heterogeneous condition with multiple etiologies, presentations, and outcomes. This prospective C&S project investigates whether baseline magnetic resonance imaging (MRI) markers can predict conversion of MCI to Alzheimer disease (AD). The focus of this C&S project is on the interrelations between entorhinal/parahippocampal, inferior and lateral temporal, posterior cingulate and precuneal gray matter atrophy, hippocampal atrophy and lateral ventricle enlargement with conversion to AD within 3 years or MCI diagnosis. The project tracks over 100 MCI subjects from identified available recourses (including the Alzheimer’s Disease Neuroimaging Initiative, ADNI).